Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fatigue01:21

Fatigue

1.1K
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
1.1K
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

4.9K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.9K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

3.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
3.4K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

2.1K
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of a Personalized Smart Cueing Device to Detect Freezing of Gait in Parkinson's Disease.

The European journal of neuroscience·2026
Same author

Recent highlights in motor recovery and rehabilitation research after stroke.

Journal of physiotherapy·2026
Same author

Accuracy of Machine Learning to Predict Upper-Limb Outcome Within the First 72 Hours Poststroke.

Stroke·2026
Same author

Prognostic accuracy of transcranial magnetic stimulation-induced motor evoked potentials on recovery of upper limb: a systematic review.

Frontiers in neurology·2026
Same author

Effects of physical exercise on cognitive impairment in patients with Alzheimer's disease, Parkinson's disease or mild cognitive impairment: a systematic review and meta-analysis.

European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity·2026
Same author

Appropriate use recommendations for digital technology in cognitive telerehabilitation for people living with Parkinson's disease.

Disability and rehabilitation. Assistive technology·2026

Related Experiment Video

Updated: Apr 4, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

17.5K

Exercise therapy for fatigue in multiple sclerosis.

Martin Heine1, Ingrid van de Port, Marc B Rietberg

  • 1Brain Center Rudolf Magnus and Center of Excellence for Rehabilitation Medicine, University Medical Center Utrecht and Rehabilitation Center De Hoogstraat, Rembrandkade 10, Utrecht, Utrecht, Netherlands, 3583TM.

The Cochrane Database of Systematic Reviews
|September 12, 2015
PubMed
Summary
This summary is machine-generated.

Exercise therapy effectively reduces fatigue in people with multiple sclerosis (MS). This review found that endurance, mixed, and other training types significantly improved self-reported fatigue, with no increased risk of MS relapses.

More Related Videos

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

644
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.4K

Related Experiment Videos

Last Updated: Apr 4, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

17.5K
The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

644
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.4K

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Clinical Trials

Background:

  • Multiple sclerosis (MS) affects 1.3 million worldwide, with fatigue being the most common and disabling symptom.
  • Disease mechanisms and inactivity contribute to MS fatigue; exercise therapy offers a potential counteracting intervention.

Purpose of the Study:

  • To evaluate the effectiveness and safety of exercise therapy for reducing fatigue in individuals with MS.
  • To compare exercise interventions against no-exercise controls or alternative treatments using self-reported fatigue measures.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials (RCTs) identified through comprehensive database searches.
  • Included RCTs focused on adults with MS, comparing exercise therapy to control conditions, with fatigue measured by validated questionnaires.
  • Methodological quality assessed using Cochrane 'risk of bias' and PEDro scales; evidence synthesized using GRADE approach.

Main Results:

  • 45 trials involving 2250 people with MS were analyzed, encompassing various exercise types like endurance, mixed, and 'other' training.
  • Meta-analysis of 26 trials showed a significant reduction in self-reported fatigue favoring exercise therapy (SMD -0.53, P < 0.01), despite heterogeneity.
  • Exercise therapy demonstrated effectiveness for endurance, mixed, and 'other' training; no significant increase in MS relapses was observed, though reporting was poor.

Conclusions:

  • Exercise therapy is a safe intervention for people with MS and can effectively reduce self-reported fatigue, particularly endurance, mixed, and 'other' training.
  • Methodological limitations exist, including lack of specific targeting of fatigue and inconsistent use of validated fatigue measures in trials.
  • Further research should address these methodological issues to optimize exercise interventions for MS-related fatigue.