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The Prognostic Value of Soluble Intercellular Adhesion Molecule 1 Plasma Level in Children With Acute Lung Injury
Mohammed A Al-Biltagi1, Ahmed Ahmed Abd ElBasset Abo-Elezz1, Khaled Talaat Abu-Ela1
11 Pediatric Department, Faculty of Medicine, Medical Complex, Tanta University, Tanta, Egypt.
Insights
Plasma soluble intercellular adhesion molecule 1 (sICAM-1) levels predict outcomes in children with acute lung injury (ALI). Higher sICAM-1 levels correlate with increased mortality and need for mechanical ventilation.
Area of Science:
- Pediatric critical care medicine
- Pulmonology
- Biomarker research
Background:
- Acute lung injury (ALI) in children presents a significant mortality risk.
- Early identification of critical cases is crucial for timely intervention.
- Soluble intercellular adhesion molecule 1 (sICAM-1) is a potential biomarker for inflammatory conditions.
Purpose of the Study:
- To assess the prognostic value of plasma sICAM-1 levels in predicting outcomes for pediatric ALI.
- To determine if sICAM-1 can aid in early recognition of severe ALI cases.
Main Methods:
- Prospective, controlled cohort study including 40 children with ALI and 30 healthy controls.
- Plasma sICAM-1 levels measured on days 1 and 3 post-ALI diagnosis in patients, and once in controls.
- C-Reactive protein measured on day 1 in both groups.
Main Results:
- Significantly elevated plasma sICAM-1 levels in ALI patients compared to controls (P = .001).
- Mortality rate in pediatric ALI was 55%.
- Higher sICAM-1 levels in non-survivors versus survivors (P < .001) at days 1 and 3.
- Positive correlation between sICAM-1 levels and mechanical ventilation duration and mortality, with stronger correlation at day 3.
Conclusions:
- Plasma sICAM-1 is a valuable prognostic biomarker in pediatric ALI.
- sICAM-1 levels effectively predict the need for mechanical ventilation and mortality risk.
- Measurement of sICAM-1 may facilitate early identification of high-risk pediatric ALI patients.
Objective:
The objective of this study was to evaluate the prognostic significance of soluble intercellular adhesion molecule 1 (sICAM-1) measurement in plasma for the prediction of outcome of acute lung injury (ALI) in children that may allow early recognition of critical cases.
Methods:
The study was performed as a prospective, controlled cohort study involving 40 children with ALI and 30 healthy children. The plasma level of sICAM-1 was measured at days 1 and 3 of development of ALI for the patient group and measured only once for the control group. C-Reactive protein was measured in both groups on day 1 only.
Results:
There was significant increase in sICAM-1 in the patient group than in the control group ( P = .001*). The mortality rate reached 55% in children with ALI. The ceased group had significantly higher plasma sICAM-1 levels both at days 1 and 3 than the survived group ( P < .001*), and there was positive correlation between plasma sICAM-1 level and both duration of mechanical ventilation and the death rate, but more significant correlation was observed with plasma sICAM-1 levels at day 3 than day 1.
Conclusion:
Plasma sICAM-1 level served as a good predictor biomarker for both mechanical ventilation duration and the mortality risk in children with ALI.
