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Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection
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Listeria meningitis complicating a patient with ulcerative colitis on concomitant infliximab and hydrocortisone

V Parihar1, S Maguire2, A Shahin2

  • 1Connolly Hospital Blanchardstown, Dublin, Ireland. vikpar37@yahoo.com.

Irish Journal of Medical Science
|September 12, 2015
PubMed

Infliximab, a monoclonal antibody directed against tumour necrosis factor, is an effective therapy for moderate-to-severe ulcerative colitis and Crohn's disease. Uncommonly, serious opportunistic infections have occurred in patients after infliximab administration. Here, we describe meningitis caused by Listeria monocytogenes developing in a 37-year-old man with ulcerative colitis refractory to intravenous corticosteroids 10 days after receiving his first infusion of infliximab. With the increasing use of tumour necrosis factor-α-neutralizing agents, clinicians should be aware of the risk of opportunistic infections caused by L. monocytogenes in patients with inflammatory bowel disease following infliximab treatment. The half-life of infliximab is 9.5 days; therefore, patients tend to be more susceptible in the immediate period following infusion. Patients receiving anti-TNF therapy should be advised to avoid foods such as soft cheeses and unpasteurized dairy products.

Keywords:
HydrocortisoneInflammatory bowel diseaseInfliximabListeria meningitis

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