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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

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Cancer-Associated Venous Thromboembolic Disease, Version 1.2015.

Michael B Streiff¹, Bjorn Holmstrom¹, Aneel Ashrani¹

¹The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Moffitt Cancer Center; Mayo Clinic Cancer Center; University of Michigan Comprehensive Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women's Cancer Center; National Blood Clot Alliance; Massachusetts General Hospital Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; Stanford Cancer Institute; Roswell Park Cancer Institute; Fox Chase Cancer Center; Vanderbilt-Ingram Cancer Center; Duke Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Memorial Sloan Kettering Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred & Pamela Buffett Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; and National Comprehensive Cancer Network.

Journal of the National Comprehensive Cancer Network : JNCCN

|September 12, 2015

Summary

Obese cancer patients require adjusted anticoagulant doses for effective venous thromboembolism (VTE) prophylaxis. New NCCN guidelines provide updated dosing recommendations to ensure optimal VTE prevention in this high-risk population.

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Area of Science:

Oncology
Hematology
Pharmacology

Background:

Venous thromboembolism (VTE) is a frequent and serious complication in cancer patients, increasing morbidity and mortality.
Risk-appropriate VTE prophylaxis is crucial for optimal cancer care in both inpatient and outpatient settings.
Obesity is a prevalent comorbidity in cancer patients and is independently associated with VTE risk, potentially affecting anticoagulant efficacy.

Purpose of the Study:

To summarize data supporting new dosing recommendations for VTE prophylaxis in obese cancer patients.
To address the impact of body weight on anticoagulant dosing for VTE prevention.
To update NCCN Guidelines for Cancer-Associated Venous Thromboembolic Disease.

Main Methods:

Review of data supporting VTE prophylaxis dosing in obese cancer patients.
Analysis of the relationship between body weight, drug clearance, and anticoagulant dose.
Development of evidence-based dosing recommendations.

Main Results:

Obesity significantly impacts VTE risk and may necessitate adjusted anticoagulant doses.
New dosing recommendations for VTE prophylaxis in obese cancer patients are proposed.
These insights aim to guide clinicians in optimizing VTE prevention for this population.

Conclusions:

Optimizing VTE prophylaxis in obese cancer patients requires careful consideration of body weight-adjusted dosing.
Adherence to updated NCCN guidelines can improve the safety and effectiveness of VTE prevention.
Further research may be warranted to refine anticoagulant strategies in diverse patient populations.