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Updated: Apr 4, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Calcium and Magnesium Use for Oxaliplatin-Induced Neuropathy: A Case Study to Assess How Quickly Evidence Translates
Deirdre R Pachman1, Kathryn Ruddy1, Lindsey R Sangaralingham1
1From the Department of Oncology, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, and Health Care Policy & Research, Mayo Clinic, Rochester, Minnesota; and Optum Labs, Cambridge, Massachusetts.
Abstract:
Substantial research efforts have focused on methods of treating and preventing oxaliplatin-associated neuropathy, the dose-limiting toxicity associated with this drug. Administration of intravenous calcium and magnesium (CaMg) before and after oxaliplatin has been the most studied approach to preventing oxaliplatin-induced neuropathy. Although early reports demonstrated potential benefit, subsequent larger trials failed to confirm the efficacy of CaMg in preventing this adverse effect. This article explores how accumulating evidence for and against the use of CaMg for preventing oxaliplatin-induced neuropathy has impacted clinical practice.
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