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Autoimmune hemolytic anemia and venous thromboembolism: A systematic review and meta-analysis
Patompong Ungprasert1, Pansakorn Tanratana2, Narat Srivali3
1Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA; Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Objective:
To investigate the risk of venous thromboembolism (VTE) among patients with autoimmune hemolytic anemia (AIHA).
Methods:
We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardized incidence ratio comparing the risk of VTE in patients with AIHA versus participants without AIHA. Pooled risk ratio and 95% confidence intervals were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird.
Results:
Out of 592 potentially relevant articles, four studies (three cohort studies and one cross-sectional study) met our inclusion criteria and were included in the data analysis. The pooled risk ratio of VTE in patients with AIHA was 2.63 (95% CI, 1.37-5.05). The statistical heterogeneity of this study was high with an I(2) of 97%.
Conclusions:
Our study demonstrated a significantly increased risk of VTE among patients with AIHA.
