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Updated: Apr 4, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Hospital disinfection challenges due to multiresistant pathogens in surgery]
D Exner1, J C Kalff1, S Engelhart2
1Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Gefäßchirurgie am Universitätsklinikum Bonn.
Abstract:
The number of antibiotic-resistant pathogens is increasing continuously while the development of new, effective antibiotics cannot be expected in the near future. Postoperative infections represent most of the nosocomial infections by now. Based on this, hygienic strategies regain importance, since a sustainable control of nosocomial infections will not succeed without the implementation of such strategies. In this article, the most important preventive strategies for prevention of infections with MRSA and 3- and 4-fold resistant gram-negative bacteria on the basis of current recommendations of the Commission for Hospital Hygiene and Infection Prevention (KRINKO) are presented.
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