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Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

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Published on: September 22, 2017

Progressive retinal structure abnormalities in multiple system atrophy.

Carlos E Mendoza-Santiesteban^1,2, Jose-Alberto Palma¹, Jose Martinez¹

¹Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.

Movement Disorders : Official Journal of the Movement Disorder Society

|September 12, 2015

Summary

Retinal nerve fiber layer and ganglion cell complex thinning progresses in Multiple System Atrophy (MSA) patients, offering a potential imaging biomarker for disease progression in clinical trials.

Keywords:

Parkinson disease ganglion cell complex multiple system atrophy optical coherence tomography retinal nerve fiber layer unified multiple system atrophy rating scale

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Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

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Published on: January 10, 2019

Area of Science:

Ophthalmology
Neurology
Biomarker Discovery

Background:

Objective measures are needed for Multiple System Atrophy (MSA) clinical trials.
Retinal thickness changes were studied to assess its utility as an imaging biomarker for MSA progression.

Purpose of the Study:

To evaluate retinal thickness changes over time in patients with MSA.
To determine the potential of retinal thickness as an imaging biomarker for disease progression in MSA.

Main Methods:

Cross-sectional and longitudinal study involving 24 MSA patients, 20 Parkinson's disease (PD) patients, and 35 controls.
High-definition optical coherence tomography (HD-OCT) and the Unified Multiple System Atrophy Rating Scale (UMSARS) were used for evaluations.
Follow-up visits were conducted for up to 26 months.

Main Results:

MSA and PD patients showed reduced retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness compared to controls.
No significant differences in RNFL and GCC thickness were observed between MSA and PD groups.
MSA patients exhibited progressive annual average losses of 3.7 μm in RNFL and 1.8 μm in GCC thickness.

Conclusions:

Visually asymptomatic MSA patients demonstrate progressive thinning of the RNFL and GCC, quantifiable by HD-OCT.
These progressive retinal changes represent a potential imaging biomarker for disease progression in future MSA clinical trials.