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Updated: Apr 4, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Nutrient Competition: A New Axis of Tumor Immunosuppression
Madhusudhanan Sukumar1, Rahul Roychoudhuri1, Nicholas P Restifo1
1Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health Bethesda, MD 20892, USA.
Abstract:
It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity.
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