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Urinary myo-inositol levels in Japanese schoolchildren with normal glucose tolerance

Eiichiro Satake, Rie Matsushita, Kazuteru Kitsuda

    Journal of Pediatric Endocrinology & Metabolism : JPEM
    |September 12, 2015
    PubMed

    Insights

    Urinary myo-inositol (UMI) levels may help detect glucose intolerance in children. This study established normal UMI ranges and identified elevated UMI differences in children with diabetes or impaired glucose tolerance.

    Area of Science:

    • Pediatric Endocrinology
    • Metabolic Research
    • Biomarker Discovery

    Background:

    • Urinary myo-inositol (UMI) levels are elevated in adult diabetic patients and increase post-glucose load.
    • The association between UMI and plasma glucose in children remains uncharacterized.
    • Investigating UMI as a potential marker for pediatric glucose intolerance is crucial.

    Purpose of the Study:

    • To determine the relationship between urinary myo-inositol and plasma glucose levels in children.
    • To assess the utility of UMI as a practical biomarker for glucose intolerance in pediatric populations.
    • To establish normative UMI ranges in healthy schoolchildren.

    Main Methods:

    • Study 1 involved 328 schoolchildren, measuring fasting and postprandial UMI to calculate the difference (ΔUMI).
    • Study 2 included 18 children with suspected diabetes, undergoing oral glucose tolerance tests and UMI measurements.
    • Statistical analysis was performed to compare ΔUMI across different glucose tolerance groups.

    Main Results:

    • The normal range for ΔUMI in schoolchildren was determined.
    • Children diagnosed with diabetes or impaired glucose tolerance exhibited significantly higher ΔUMI values compared to those with normal glucose tolerance.
    • These findings suggest a correlation between altered glucose metabolism and UMI levels in children.

    Conclusions:

    • The studies successfully defined the normal range of UMI in children.
    • Urinary myo-inositol shows potential as a novel biomarker for the early detection of glucose intolerance in pediatric patients.
    • Further research is warranted to validate UMI's role in pediatric metabolic health screening.
    Abstract

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