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An efficient S-NO-polysilsesquioxane nano-platform for the co-delivery of nitric oxide and an anticancer drug
Meng-Ren Wang1, Shih-Jiuan Chiu, Hung-Chang Chou
1School of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan, Republic of China. tmhu@ndmctsgh.edu.tw.
Abstract:
Codelivery of nitric oxide (NO) and drugs based on a single nanocarrier is a promising therapeutic strategy. Here, we report a one-step nanoprecipitation method to generate nanoparticles that possess simultaneous NO-donating and doxorubicin releasing properties. S-Nitroso polysilsesquioxane acts like an avid "drug sponge" that attracts drug molecules into nanospheres.
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