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Upper Gastrointestinal Bleeding in Children: The Role of Helicobacter pylori Infection and Non-steroidal
1Sisli Hamidiye Etfal Education and Research Hospital, Department of Pediatric Gastroenterology, 34377 Sisli, Istanbul, Turkey. mervekesim@yahoo.com.
Insights
Non-steroidal anti-inflammatory drugs (NSAIDs), specifically ibuprofen and acetylsalicylic acid, are significant causes of upper gastrointestinal bleeding in children. Helicobacter pylori infection did not show a significant link to this condition in pediatric patients.
Area of Science:
- Pediatric Gastroenterology
- Drug-induced Gastrointestinal Disorders
Background:
- Upper gastrointestinal bleeding (UGIB) is a serious condition in children.
- The roles of non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection in pediatric UGIB require further elucidation.
Purpose of the Study:
- To investigate the association between NSAID use and H. pylori infection with the occurrence of UGIB in pediatric patients.
Main Methods:
- Retrospective analysis of medical records for 188 pediatric patients who underwent endoscopy for UGIB.
- Data collected included patient demographics, drug intake history, and H. pylori status.
Main Results:
- NSAID use, particularly ibuprofen and acetylsalicylic acid, was significantly associated with UGIB in children (p < 0.05).
- H. pylori infection was detected in 20.7% of patients but was not found to be statistically significant in relation to UGIB (p > 0.05).
- No significant relationship was observed between NSAID intake and H. pylori co-infection.
Conclusions:
- Ibuprofen and acetylsalicylic acid are significant etiological factors for UGIB in the pediatric population.
- H. pylori infection does not appear to play a significant role in pediatric UGIB.
- Co-occurrence of NSAID use and H. pylori infection did not show a significant relationship in this cohort.
Objective:
To study the role of non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection in the aetiology of upper gastrointestinal bleeding (UGIB) in children.
Subjects And Methods:
One hundred and eighty-eight patients (82 girls, 106 boys; mean age 8.43 ± 5.24 years), admitted to the paediatric gastroenterology unit because of UGIB and who underwent endoscopic examination, were studied from their medical records, retrospectively.
Results:
Upper gastrointestinal bleeding was observed in 188 (8.29%) of 2266 patients. The mucosal causes related to the oesophagus, stomach and duodenum were found at the rate of 37%, 58% and 24.5%, respectively with endoscopic examination. The location of bleeding could not be determined in 14.4% of the patients. History of drug intake before admitting to hospital was present in 40 patients (21.3%). When we examined these forty patients, 35% were on acetylsalicylic acid, 47.5% were on ibuprofen and 17.5% were on NSAIDs. Ibuprofen versus acetylsalicylic acid usage was found to be highly significant (p < 0.05) for UGIB. Helicobacter pylori was found in 20.7% of the patients. The relationship between H pylori and UGIB was not found statistically significant (p > 0.05). The relationship between drug intake and presence of H pylori infection was not found significant in our patients (p > 0.05).
Conclusion:
Ibuprofen and acetylsalicylic acid intake were found significant in the aetiology of UGIB in children. There was no significant connection with Helicobacter pylori infection in children with UGIB. We did not find a significant relationship with drug intake and H pylori infection.
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