[Effects of experimental coronary artery stenosis on platelet function]

In mild stenosis, coronary blood flow (CBF) was unchanged, thromboxane (TX) B2/6-ketoprostaglandin (PG) F1a ratio rose with no change in PAgT. In critical stenosis, CBF was slightly decreased, PAgT, TXB2 and TXB2/PGF1a ratio rose with cyclical reduction in CBF. In severe stenosis, CBF was markedly decreased; PAgT, TXB2 and TXB2/6-keto-PGF1a ratio rose and 6-keto-PGF1a decreased with cyclical blood flow reduction. Histopathologic examination confirmed the presence of damaged endothelial cell with coronary thrombosis and platelet/fibrin microemboli in critical and severe stenosis. It is concluded that coronary artery stenosis leads to a damage of endothelial cell, which causes an abnormality in platelet function and coronary thrombosis.