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[Changes in the deformability of erythrocytes and 2,3-DPG in coronary artery stenosis]
Insights
Red blood cell (RBC) deformability and 2,3-diphosphoglycerate (2,3-DPG) decrease with coronary artery stenosis severity. Salvia may improve RBC function and microcirculation in coronary artery disease.
Area of Science:
- Cardiology
- Hematology
- Physiology
Background:
- Coronary artery disease (CAD) is associated with impaired microcirculation.
- Red blood cell (RBC) deformability is crucial for blood flow in narrow vessels.
- Reduced RBC deformability may contribute to microcirculatory dysfunction in CAD.
Purpose of the Study:
- To investigate changes in RBC deformability and 2,3-diphosphoglycerate (2,3-DPG) in patients with coronary artery stenosis.
- To examine the influence of contrast media, Salvia, and Nifedipine on these parameters.
Main Methods:
- Measurement of RBC deformability index.
- Quantification of 2,3-DPG levels within RBCs.
- Assessment of parameters before and after interventions (contrast medium, Salvia, Nifedipine).
Main Results:
- RBC deformability and 2,3-DPG levels were inversely proportional to the degree of coronary artery lesions (P < 0.01).
- A significant decrease in RBC deformability was observed after contrast medium administration.
- Salvia demonstrated a potential to increase both RBC deformability and 2,3-DPG.
- Nifedipine showed a potential to enhance RBC deformability.
Conclusions:
- Microcirculatory dysfunction and impaired RBC deformability are likely present in CAD.
- Salvia may offer a therapeutic potential for normalizing decreased RBC deformability and 2,3-DPG.
- Salvia may improve microcirculatory blood flow velocity in patients with CAD.
Abstract:
The changes of deformability of RBC and 2,3-DPG in RBC in patients with coronary artery stenosis and the influence of some factors on them were studied. The results showed that: (1) the deformability index was inversely proportional to the degree of lesions of coronary vessels (P less than 0.01); (2) the 2,3-DPG was inversely proportional to the degree of lesions of coronary vessels (P less than 0.01); (3) there was a significant decrease in deformability index after using contrast medium; (4) Saliva may increase deformability of RBC and 2,3-DPG; (5) Nifedipine may increase deformability of RBC. These results showed: (1) the possible existence of microcirculatory dysfunction in coronary artery disease and in parallel of impaired deformability of RBC; (2) the possibility of normalization of the decreased deformability of 2,3-DPG in RBC by Salvia; (3) the possibility of increase of velocity of blood flow in microcirculation in coronary artery disease by Salvia.