Related Experiment Video
Updated: Apr 4, 2026

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Low-concentration uranium enters the HepG2 cell nucleus rapidly and induces cell stress response
Yann Guéguen1, David Suhard2, Clémentine Poisson1
1Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux-Roses, France.
Abstract:
This study aimed to compare the cell stress effects of low and high uranium concentrations and relate them to its localization, precipitate formation, and exposure time. The time-course analysis shows that uranium appears in cell nuclei as a soluble form within 5 min of exposure, and quickly induces expression of antioxidant and DNA repair genes. On the other hand, precipitate formations began at the very beginning of exposure at the 300-μM concentration, but took longer to appear at lower concentrations. Adaptive response might occur at low concentrations but are overwhelmed at high concentrations, especially when uranium precipitates are abundant.
More Related Videos
10:50Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
Published on: April 24, 2021
09:23Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability
Published on: June 21, 2015
Related Concept Videos
Regulation of the Unfolded Protein Response
Stringent Response in E. coli
The Unfolded Protein Response
Other Stress Responses in Bacteria
DNA Damage can Stall the Cell Cycle
DNA Damage Can Stall the Cell Cycle