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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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The intestinal microbiome in human disease and how it relates to arthritis and spondyloarthritis

Mary-Ellen Costello1, Philip C Robinson2, Helen Benham3

  • 1The University of Queensland, The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD, 4102, Australia.

Best Practice & Research. Clinical Rheumatology
|September 13, 2015
PubMed

Insights

Alterations in the human gut microbiome are linked to immune-mediated diseases like spondyloarthropathies. This review explores host genetics, gut microbiome interactions, and potential therapies for these conditions.

Area of Science:

  • Microbiome research
  • Immunology
  • Genetics

Background:

  • The human microbiome plays a crucial role in health and disease.
  • Dysbiosis, or imbalance in the gut flora, is associated with immune-mediated conditions.
  • Spondyloarthropathies are a group of inflammatory diseases linked to immune system dysfunction.

Purpose of the Study:

  • To review the current understanding of the interplay between host genetics and the gut microbiome in spondyloarthropathies.
  • To explore how this interaction influences disease pathogenesis.
  • To discuss potential therapeutic strategies targeting the gut microbiome.

Main Methods:

  • Literature review of current research on host genetics, gut microbiome, and spondyloarthropathies.
  • Analysis of sequencing technologies and 16S rRNA gene profiling in microbiome characterization.
  • Examination of novel therapies like probiotics and fecal microbiota transplantation.

Main Results:

  • Host genetics and gut microbiome composition are intricately linked in the development of spondyloarthropathies.
  • Specific microbial communities and genetic factors contribute to disease pathogenesis.
  • Emerging therapies show promise in modulating the gut microbiome for treatment.

Conclusions:

  • Understanding the host-gut microbiome axis is critical for deciphering spondyloarthropathies.
  • Targeting the gut microbiome offers a promising avenue for novel therapeutic interventions.
  • Further research is needed to fully elucidate these complex interactions and optimize treatments.
Keywords:
DysbiosisFaecal microbiota transplantIntestinal microbiomeSpondyloarthritis

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