Related Experiment Video
Updated: Jul 15, 2026
Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
Published on: January 2, 2013
A rare fast variant of red cell 6-phosphogluconate dehydrogenase found in Japanese
Abstract:
In a Japanese family, we discovered by starch-gel electrophoresis a fast variant of 6-phosphogluconate dehydrogenase (PGD) in red blood cells. This variant is described here for the first time and temporarily named AX. It showed three PGD bands, the usual PGD A band and two faster-moving bands than PGD A. The ratio of the staining intensity of these bands was 2:2:1 in the order of increasing mobility, and negative sensitivity was noted toward 2-mercaptoethanol. Its genotype appeared to be heterozygous PGDA/PGDX, based on examinations of the PGD band composition and the pedigree of the family. It may possibly correspond to the PGD "Kadar" variant (PGDA/PGDKadar), with which it was quite similar, in electrophoretic mobility, staining intensity and sensitivity to 2-mercaptoethanol.
Related Concept Videos
01:31Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
02:45Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
02:32Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
01:31Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
01:27Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
01:19Rh Blood Group