LncReg: a reference resource for lncRNA-associated regulatory networks

Area of Science:

• Genomics
• Molecular Biology
• Bioinformatics

Background:

• Long non-coding RNAs (lncRNAs) play crucial roles in biological regulation.
• The increasing number of identified lncRNAs and their complex regulatory roles create literature challenges for researchers.

Purpose of the Study:

• To consolidate and present validated lncRNA regulatory relationships.
• To develop a user-friendly database, LncReg, for easier access to lncRNA data.
• To facilitate bioinformatics research and understanding of lncRNA functions.

Main Methods:

• Curated a database of 1081 validated lncRNA-associated regulatory entries.
• Included 258 non-redundant lncRNAs and 571 non-redundant genes in the dataset.
• Developed the LncReg database accessible online.

Main Results:

• Established LncReg with a comprehensive collection of lncRNA regulatory data.
• The database contains validated interactions, offering insights into regulatory networks.
• Provides a valuable resource for studying lncRNA functional roles.

Conclusions:

• LncReg offers a centralized platform for lncRNA regulatory information.
• The database aids researchers in navigating the complexity of lncRNA literature.
• Facilitates comprehensive bioinformatics analysis and functional studies of lncRNAs.