Related Experiment Video
Updated: Apr 4, 2026

High-pressure, High-temperature Deformation Experiment Using the New Generation Griggs-type Apparatus
Published on: April 3, 2018
Compaction behavior and deformation mechanism of directly compressible textured mannitol in a rotary tablet press
Nicolas Tarlier1, Ian Soulairol1, Bernard Bataille1
1Institut Charles Gerhardt UMR5253 Equipe MACS, UFR Sciences Pharmaceutiques et Biologiques - Université de Montpellier, France.
Abstract:
Textured mannitol powder is widely used as a pharmaceutical excipient for tablet compaction. In order to choose the right tableting parameters, it is necessary to understand its mechanical behavior during deformation under industrial tableting conditions. The aim of this study was to evaluate the mechanical behavior during deformation of a textured mannitol using a rotary tablet press simulator. Mean yield pressure (Py) obtained by Heckel modeling, Walker coefficients (W) and Stress Rate Sensitivity (SRS) were compared to reference excipients, known for either their plastic (microcrystalline cellulose) or fragmentary (lactose and dibasic calcium phosphate) deformation behavior. Py, W and SRS values showed that the studied textured mannitol has a fragmentary deformation mechanism. Furthermore, this mechanical behavior was not sensitive to lubrication, which is characteristic of fragmentary excipients.
More Related Videos
06:34Finite Element Modeling for the Simulation of the Quasi-Static Compression of Corrugated Tapered Tubes
Published on: January 6, 2023
09:00Visualization of Failure and the Associated Grain-Scale Mechanical Behavior of Granular Soils under Shear using Synchrotron X-Ray Micro-Tomography
Published on: September 29, 2019
Related Concept Videos
In Vitro Drug Dissolution: Compendial Testing Models I
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Behavior of Concrete Under Compressive Load
As the concrete specimen fractures under...
In Vitro Drug Dissolution: Compendial Testing Models II