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Updated: Apr 4, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
An unusual thrombolytic therapy decision in prosthetic valve thrombosis during early pregnancy
Erkan Köklü1, İsa Öner Yüksel1, Zehra Erkal1
1Department of Cardiology, Antalya Training and Research Hospital, Antalya, Turkey.
Abstract:
Pregnancy is among the risk factors for mechanical valve thrombosis, and even though thrombolytic therapy is contraindicated during pregnancy, it may be used in the treatment of this life-threatening complication. This case report describes a pregnant patient, whose echocardiogram showed evident gradient increase on her mechanical prosthetic mitral valve, and who was treated successfully with tissue plasminogen activator for mechanical valve thrombosis.
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