Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging
Anders M Fjell1, Markus H Sneve2, Håkon Grydeland2
1Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Physical medicine and rehabilitation, Unit of Neuropsychology, Oslo University Hospital, Oslo, Norway.
Episodic memory decline is linked to changes in resting-state functional connectivity (rsFC). The relationship between rsFC and memory differs significantly across age groups, impacting cognitive aging research.
Area of Science:
- Cognitive Neuroscience
- Neuroimaging
- Aging Research
Background:
- Episodic memory decline is a key concern in aging.
- Resting-state functional connectivity (rsFC) changes may underlie cognitive decline.
Purpose of the Study:
- To investigate the relationship between changes in rsFC and episodic memory decline over time.
- To examine age-dependent differences in the rsFC-memory relationship.
Main Methods:
- Longitudinal study with 119 healthy participants (20-83 years) over 3.5 years.
- Magnetic resonance imaging (MRI) for rsFC assessment and verbal recall testing.
- Replication using a simulation model and a cross-sectional recognition memory task.
Main Results:
- Recall change correlated with rsFC changes across widespread brain areas, independent of atrophy.
- A positive rsFC-memory relationship was observed in older adults.
- A negative rsFC-memory relationship was found in younger and middle-aged adults.
Conclusions:
- Memory decline is associated with altered rsFC in an age-dependent manner.
- The cognitive impact of rsFC changes varies across the lifespan.
- Further research is needed to elucidate the mechanisms behind these age-varying relationships.
More Related Videos
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
08:43Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
Related Concept Videos
Role of Cerebellum and Prefrontal Cortex in Memory
Cognitive Development During Adulthood
Higher Mental Functions of Brain: Learning and Memory
Role of Hippocampus in Memory
Storage
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
