Related Experiment Video
Updated: Feb 9, 2026
06:30
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
Published on: May 23, 2025
1.0K
Advances in therapeutics for chronic hepatitis B
Ninghan Yang1, Antonio Bertoletti2,3
1Viral Hepatitis Laboratory, Singapore Institute of Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. yang_ninghan@sics.a-star.edu.sg.
Hepatology International
|September 14, 2015
Summary
New hepatitis B virus (HBV) therapies focus on novel antivirals and immunotherapies. These strategies aim to inhibit viral replication and restore immune control for a potential cure in chronic hepatitis B patients.
Area of Science:
- Hepatology and Virology
- Immunology and Infectious Diseases
Background:
- Chronic hepatitis B infection is a significant global health issue, increasing the risk of hepatocellular carcinoma.
- Current treatments, including nucleos(t)ide analogues and interferon alpha, have limited efficacy.
- Understanding the hepatitis B virus (HBV) life cycle and host immune responses is crucial for developing new therapies.
Purpose of the Study:
- To review emerging therapeutic strategies for chronic hepatitis B.
- To discuss novel antiviral drugs targeting HBV replication and persistence.
- To explore immunotherapies aimed at restoring immune-mediated viral control.
Main Methods:
- Review of recent scientific literature on HBV pathogenesis and treatment.
- Analysis of novel therapeutic targets in the HBV life cycle.
- Evaluation of advancements in HBV-specific innate and adaptive immune responses.
Main Results:
- Development of novel antiviral agents to inhibit HBV replication.
- Advancement of immunotherapies to enhance host immune control of HBV.
- Identification of potential strategies for a sustained cure for chronic hepatitis B.
Conclusions:
- Novel therapeutic strategies targeting HBV replication and host immune responses hold promise for chronic hepatitis B.
- A combination of antiviral and immunotherapy may be necessary for a sustained cure.
- Further research is needed to translate these findings into effective clinical treatments.
More Related Videos
Related Concept Videos
01:26Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
248
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
248
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
281
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
281
01:21Hepatic Portal System
6.1K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
6.1K
01:13Therapeutic Index
6.9K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.9K
02:22Overview of Advanced Functional Groups
30.1K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.1K
00:56Extraction: Advanced Methods
1.2K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K