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Related Concept Videos

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
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Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
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Abnormal GABAergic function and face processing in schizophrenia: A pharmacologic-fMRI study.

Ivy F Tso1, Yu Fang1, K Luan Phan2

  • 1Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

Schizophrenia Research
|September 14, 2015
PubMed
Summary
This summary is machine-generated.

Schizophrenia patients exhibit altered brain responses to lorazepam, indicating abnormal gamma-aminobutyric acid (GABA) system function during face processing. This visual cortex dysfunction is linked to negative affect and social deficits.

Keywords:
BenzodiazepineEmotionPsychosisSocial cognitionfMRI

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • The gamma-aminobutyric acid (GABA) system is implicated in schizophrenia.
  • Previous research indicated abnormal GABAergic function in processing negative visual stimuli.

Purpose of the Study:

  • To investigate GABAergic mechanisms in face processing and social appraisal in schizophrenia.
  • To map brain activity using functional MRI (fMRI) during a benzodiazepine challenge.

Main Methods:

  • 14 schizophrenia patients (SZ) and 13 healthy controls (HC) underwent fMRI.
  • Participants performed the Socio-emotional Preference Task (SePT) with emotional faces.
  • Benzodiazepine (lorazepam) and saline challenges were administered in a single-blinded manner.

Main Results:

  • Both groups activated medial prefrontal cortex/anterior cingulate during the SePT.
  • A significant drug-by-group interaction occurred in the medial occipital cortex: SZ showed increased BOLD signal to lorazepam, while HC showed decreased signal.
  • Altered lorazepam response in SZ correlated with increased negative affect.

Conclusions:

  • Abnormal GABAergic function in the visual cortex is associated with impaired face processing and negative affect in schizophrenia.
  • Visual processing deficits may contribute to socio-emotional impairments in schizophrenia.