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Quantitative analysis of the capillary network of aged APPswe/PS1dE9 transgenic mice
Gitte Nykjær Nikolajsen1, Kamila Anna Kotynski1, Morten Skovgaard Jensen1
1Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
Abstract:
A combination of immunohistochemical and stereological techniques were used to investigate the capillary network in the cerebral cortex of 18-month-old APPswe/PS1dE9 transgenic (Tg) mice and control littermates. Data regarding total capillary length, segment number, diffusion radius, and pericyte number are presented. The total length was 60 meters and there was a one-to-one relationship between the number of capillary segments and pericytes in both groups. Significant differences were not observed in the Tg and wild-type controls indicating that the Alzheimer's-like amyloidosis produced in this Tg mouse has a minimal affect on the structural integrity of the cerebral capillary network.
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