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Related Experiment Video

Updated: Apr 4, 2026

Development and Characterization of In Vitro Microvessel Network and Quantitative Measurements of Endothelial [Ca2+]i and Nitric Oxide Production

Development and Characterization of In Vitro Microvessel Network and Quantitative Measurements of Endothelial [Ca2+]i and Nitric Oxide Production

Published on: May 19, 2016

Review: in vitro microvessel models.

Max I Bogorad¹, Jackson DeStefano¹, Johan Karlsson¹

¹Institute for Nanobiotechnology (INBT), 100 Croft Hall, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, Maryland 21218, USA. searson@jhu.edu.

|September 15, 2015

Summary

This summary is machine-generated.

Researchers review state-of-the-art perfusable microvessel models. These engineered systems advance vascular research and artificial organ development, offering diverse fabrication methods and applications.

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Last Updated: Apr 4, 2026

Development and Characterization of In Vitro Microvessel Network and Quantitative Measurements of Endothelial [Ca2+]i and Nitric Oxide Production

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Area of Science:

Biomedical Engineering
Vascular Biology
Tissue Engineering

Background:

Perfusable microvessel models are crucial for studying vascular phenomena and vascularizing artificial organs.
Advances in microfabrication, microfluidics, biomaterials, stem cell technology, and tissue engineering have enabled the development of diverse models.

Purpose of the Study:

To review the current state-of-the-art in perfusable microvessel models.
To summarize various fabrication methods, their advantages, and limitations.

Main Methods:

Review of existing literature on perfusable microvessel models.
Analysis of different fabrication techniques, including microfluidics and tissue engineering approaches.

Main Results:

A wide array of perfusable microvessel models with varying complexity and physiological relevance exist.
These models utilize diverse technologies, including stem cell integration.

Conclusions:

Perfusable microvessel models represent a versatile toolkit for vascular research.
Ongoing advancements continue to enhance their utility for applications such as artificial organ vascularization.