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Related Experiment Video

Updated: Apr 4, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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Selective internal radiation therapy for liver malignancies.

J A G Moir1, J Burns1, J Barnes1

  • 1Departments of Hepatopancreatobiliary and Transplant Surgery, Freeman Hospital, Newcastle upon Tyne, UK.

The British Journal of Surgery
|September 15, 2015
PubMed
Summary

Selective internal radiation therapy (SIRT) can reduce liver tumor size, potentially aiding surgical candidates. This study evaluated its effectiveness in patient selection and tumor downsizing for liver metastases and hepatocellular carcinoma.

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Area of Science:

  • Interventional Radiology
  • Oncology
  • Hepatobiliary Medicine

Background:

  • Selective internal radiation therapy (SIRT) is a non-ablative treatment for liver tumors, aiming to reduce tumor bulk.
  • This study investigated optimal patient selection and the role of SIRT in tumor downsizing.

Purpose of the Study:

  • To determine optimal patient selection criteria for SIRT.
  • To evaluate SIRT's efficacy as a tumor downsizing modality prior to potential resection.

Main Methods:

  • Retrospective analysis of 44 patients undergoing SIRT between 2011 and 2014.
  • Tumor response assessed via radiological criteria (RECIST on CT/MRI) and biological markers.
  • Analysis included tumor size changes (sum of diameters) and tumor markers.

Main Results:

  • SIRT demonstrated tumor reduction in hepatocellular carcinoma (HCC) and neuroendocrine tumors, but not colorectal cancer metastases.
  • Biological markers showed improvement in 12 of 17 assessed patients.
  • Six- and 12-month survival rates were 71% and 41%, respectively. No significant survival difference based on RECIST response or primary pathology.

Conclusions:

  • Selective internal radiation therapy can effectively downsize liver tumors.
  • SIRT may serve as a valuable bridge to surgery for patients with borderline resectable tumors.