Related Experiment Video
Updated: Apr 4, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Febuxostat-associated drug reaction with eosinophilia and systemic symptoms (DRESS)
H-Y Chou1, C-B Chen2,3, C-Y Cheng1
1Clinical Pharmacy Division, Department of Pharmacy, Chang Gung Memorial Hospital, Linkou, Taiwan.
What Is Known And Objective:
Febuxostat is recommended as an alternative drug for gouty patients with a history of allopurinol hypersensitivity or carrying the HLA-B*5801 allele.
Case Summary:
An 81-year-old man with the medical history of gout presented to our clinic with generalized rashes for 2 days. After taking febuxostat for 2 days, he developed generalized skin rash with high fever. Laboratory tests showed elevated liver enzymes and acute kidney injury.
What Is Known And Objective:
This is the first identified case of febuxostat-associated DRESS. Febuxostat should be withdrawn immediately when DRESS is observed to avoid further serious complications.
Related Concept Videos
Allergic Drug Reactions
Drug Toxicity: Allergic Reactions
Hypersensitivity Reactions: Immune-Complex Reactions
Allergic Reactions
Allergic Reactions: Anaphylaxis
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

