Related Experiment Video
Updated: Apr 4, 2026
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
Published on: December 15, 2014
Can MRI biomarkers at 3 T identify low-risk ductal carcinoma in situ?
Habib Rahbar1, Sana Parsian1, Diana L Lam1
1University of Washington, Seattle Cancer Care Alliance, Department of Radiology, Breast Imaging Section, 825 Eastlake Avenue East, P.O. Box 19023, Seattle, WA 98109-1023, USA.
Objective:
The objective was to explore whether 3-T magnetic resonance imaging (MRI) can identify low-risk ductal carcinoma in situ (DCIS).
Methods:
Dynamic contrast-enhanced and diffusion-weighted (DWI) MRI features of 36 DCIS lesions [8 low risk, Van Nuys Pathologic Classification (VNPC) 1; 28 high risk, VNPC 2/3] were reviewed. An MRI model that best identified low-risk DCIS was determined using multivariate logistic regression.
Results:
Low-risk DCIS exhibited different DWI properties [i.e., higher contrast-to-noise ratio (P=.02) and lower normalized apparent diffusion coefficients (P=.04)] than high-risk DCIS. A model combining these DWI features provided best performance (area under receiver operating characteristic curve =0.86).
Conclusions:
DWI may help identify DCIS lesions requiring less therapy.
