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Hydroxyurea interferes with point-of-care creatinine testing in children with sickle cell anemia.

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Ten Years of Hydroxyurea for Ugandan Children with Sickle Cell Anemia.

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Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
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Hydroxyurea therapy for sickle cell anemia.

Patrick T McGann1, Russell E Ware1

  • 1a Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center , Cincinnati , OH, USA russell.ware@cchmc.org.

Expert Opinion on Drug Safety
|September 15, 2015
PubMed
Summary
This summary is machine-generated.

Hydroxyurea is a safe and effective treatment for sickle cell anemia (SCA), a severe inherited blood disorder. Broader use of this medication can improve patient outcomes and should be standard care, even in low-resource settings.

Keywords:
fetal hemoglobinhemoglobinopathieshydroxyureasickle cell anemia

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Area of Science:

  • Hematology
  • Pharmacology
  • Genetics

Background:

  • Sickle cell anemia (SCA) is a severe inherited hemoglobin disorder impacting millions globally.
  • Hydroxyurea is the primary disease-modifying therapy for SCA, with over 30 years of evidence supporting its efficacy and safety.
  • Despite its benefits, hydroxyurea remains underutilized in SCA management.

Purpose of the Study:

  • To review the pharmacology, clinical benefits, laboratory benefits, and safety of hydroxyurea for SCA treatment.
  • To provide a comprehensive understanding of hydroxyurea as a safe and effective medication for SCA.

Main Methods:

  • Systematic review of existing evidence on hydroxyurea therapy for SCA.
  • Summary of pharmacological, clinical, and safety data.
  • Analysis of hydroxyurea's role in altering the natural history of SCA.

Main Results:

  • Hydroxyurea has demonstrated a strong safety and efficacy profile over three decades of use.
  • Evidence supports hydroxyurea as a beneficial treatment for improving clinical and laboratory outcomes in SCA patients.
  • The review consolidates evidence reinforcing hydroxyurea's established benefits.

Conclusions:

  • Hydroxyurea therapy should be considered the standard-of-care for sickle cell anemia.
  • Early and widespread adoption of hydroxyurea can significantly improve the quality of life and longevity for individuals with SCA.
  • Expanding hydroxyurea access to low-resource regions, particularly sub-Saharan Africa, is crucial due to the high burden of SCA.