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Ocular involvement in systemic lupus erythematosus.

Janine M Preble1, Sukhum Silpa-archa, C Stephen Foster

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Systemic Lupus Erythematosus (SLE)

Background:

  • Ocular manifestations are common in Systemic Lupus Erythematosus (SLE).
  • Retinal vasculitis and optic neuritis are severe complications that threaten vision.
  • Ocular symptoms can indicate widespread, potentially fatal systemic inflammation.

Purpose of the Study:

  • To review current understanding and management of ocular manifestations in SLE.
  • To emphasize the importance of early detection and treatment of vision-threatening complications.
  • To discuss emerging therapies for SLE and its ocular sequelae.

Main Methods:

  • Review of existing literature on SLE ocular manifestations.
  • Analysis of treatment strategies for ocular complications.
  • Evaluation of recent advancements in SLE systemic therapy, including biologics.

Main Results:

  • Ophthalmologists have various medications to treat SLE-related ocular issues.
  • Effective management requires addressing both systemic disease and active ocular complications.
  • Biologic agents are increasingly studied for their efficacy in managing systemic SLE.

Conclusions:

  • SLE can manifest initially through ocular symptoms, necessitating ophthalmologist awareness.
  • Adequate knowledge for detection and treatment is vital to prevent vision and life-threatening outcomes.
  • Further research is needed to identify optimal therapies with minimal side effects.