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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Source And Potency Of Stem Cells01:27

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Renewal of Intestinal Stem Cells01:23

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Multipotency and Niche of Bulge Stem Cell01:06

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Related Experiment Video

Updated: Apr 3, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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Odontogenic epithelial stem cells: hidden sources.

Sivan Padma Priya1,2, Akon Higuchi3,4,5, Salem Abu Fanas2

  • 1Department of Basic Medical Science, Ajman University of Science and Technology-Fujairah Campus, Al Fujairah, United Arab Emirates.

Laboratory Investigation; a Journal of Technical Methods and Pathology
|September 15, 2015
PubMed
Summary
This summary is machine-generated.

Identifying new sources of odontogenic epithelial stem cells is crucial for bioengineered tooth regeneration. This research explores untapped human sources for potential enamel formation and regenerative medicine applications.

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Area of Science:

  • Dental stem cell research
  • Regenerative medicine
  • Bioengineering

Background:

  • Tooth formation relies on epithelial-mesenchymal interactions.
  • Dental mesenchymal stem cells are well-studied, but odontogenic epithelial stem cells are less explored due to their limited availability after enamel formation.
  • Reconstructing odontogenic epithelium is essential for bioengineered tooth development and natural enamel production.

Purpose of the Study:

  • To identify and discuss untapped sources of human odontogenic epithelial stem cells.
  • To explore the potential of these stem cells in regenerative medicine, particularly for enamel formation.
  • To advance the goal of constructing a bioengineered tooth.

Main Methods:

  • Literature review and discussion of existing knowledge on dental stem cell sources.
  • Identification of potential postnatal sources of odontogenic epithelial stem cells.
  • Exploration of applications in regenerative medicine.

Main Results:

  • Several untapped sources of human odontogenic epithelial stem cells were identified, including the active dental lamina, gubernaculum cord, epithelial cell rests of Malassez, and reduced enamel epithelium.
  • These stem cells hold potential for regenerating enamel and other dental tissues.
  • The findings support the feasibility of bioengineered tooth construction.

Conclusions:

  • Untapped sources of odontogenic epithelial stem cells exist in humans beyond early development.
  • These stem cells offer promising avenues for regenerative dentistry and bioengineered tooth replacement.
  • Further research into these sources could overcome limitations in current bioengineered tooth development.