[Endometrial carcinoma in cases under 45 years of age]

Twelve cases of endometrial carcinoma admitted to the I-st Clinic of Obstetrics and Gynecology of Iaşi in the interval 1983-1988 are presented. The patients' age ranged between 33 years (1 case) and 45 years (1 case) with a mean age of 41.3 years. This study was underwent given the increased frequency of this lesion in the premenopausal women (9.3% of all cases recorded in the interval under study). The incidence of the disturbed menstrual cycle was of 58%, that of obstetrical antecedents and obesity of 33% and 50%, respectively. In two cases there was a carcinoma "in situ", the remainder of cases presenting disease in stage I (FIGO classification). The diagnosis was made preoperatively in 7 cases, the other 5 patients being operated upon for uterine fibromatosis. Adenocarcinoma was the most common histological type. The need of ascertaining the etiology of metrorrhagias no matter of patients' age and the role of risk factors and some methods of detection (endometrial cytology, endometrial biopsy) are underlined.