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Cerebral vasospasm in a double-injection model in rabbit.
1Division of Neurosurgery, Second University of Rome, Tor Vergata, Italy.
Surgical Neurology
|December 1, 1989
Summary
This study shows that experimental subarachnoid hemorrhage in rabbits causes cerebral vasospasm peaking around day three. High mortality limits this model
Area of Science:
- Neurology
- Vascular Surgery
- Experimental Medicine
Background:
- Subarachnoid hemorrhage (SAH) can lead to dangerous cerebral vasospasm.
- Understanding the timing and severity of vasospasm is crucial for developing effective treatments.
Purpose of the Study:
- To assess the occurrence and timing of cerebral vasospasm after an experimental SAH in rabbits.
- To evaluate a double-injection SAH model for its efficacy and limitations.
Main Methods:
- Sixty-nine rabbits underwent a double-injection SAH model.
- Digital subtraction angiography was performed at 1, 3, or 8 days post-SAH.
- Basilar artery and extracranial vertebral artery diameters were measured to assess vasospasm.
Main Results:
- Cerebral vasospasm was consistently observed, peaking around the third day after SAH.
- A trend indicated maximum spasmogenic activity at day three.
- The model reproduced cerebral vascular spasm but had a high mortality rate (50%) in specific protocols.
Conclusions:
- The double-injection SAH model in rabbits effectively induces cerebral vasospasm.
- The peak vasospasm occurs approximately three days after repeated SAH.
- High animal mortality limits the practical utility of this model for repeated angiographic studies.