[Study on the invasiveness of mouse uterine cervix carcinoma cell (U14) implanted in mouse testis]

A good invasion and metastasis pattern was observed after implanting of U14 tumor cells subcapsular in testis, which provided a new model in vivo for studying tumor invasion and metastasis. The transplantability of U14 tumor-inoculation was 90%, retaining high metastasis in lymph-node (88.8%) and lung (77.7%). On the first day after implantation, U14 tumor cells were in a state of relative rest. On the 3rd day, tumor cells began to proliferate and invade the neighboring tissue along the natural space between seminiferous tubules. Degenerative and atrophic changes of seminiferous tubules appeared in the invasion areas. The process of invasion can be divided into 4 stages, namely latency, proliferation, early invasion and late invasion.