Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

11.0K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
11.0K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

2.6K
2.6K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.6K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.6K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

1.9K
1.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

5.1K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.7K
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SPICE: A Robust Computational Framework for Identifying Copy Number Variations in Spatial Transcriptomics.

bioRxiv : the preprint server for biology·2026
Same author

Association between elemental concentrations and chemotherapy-related acute adverse events in patients with nasopharyngeal carcinoma.

Pharmacological reports : PR·2026
Same author

A review of spontaneous bone metastases in domestic and laboratory animals.

Journal of bone oncology·2026
Same author

STDrug enables spatially informed personalized drug repurposing from spatial transcriptomics.

bioRxiv : the preprint server for biology·2026
Same author

Amoeboid-mesenchymal transition and the proteolytic control of cancer invasion plasticity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Preliminary study of cyto-impedance: Molecular profiling of functional impedance in motility-promoting treatment of normal cells.

Biochemistry and biophysics reports·2026

Related Experiment Video

Updated: Apr 3, 2026

The Soft Agar Colony Formation Assay
08:01

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

114.4K

Wnt3a: functions and implications in cancer.

Sha He1,2, Yi Lu3,4, Xia Liu5,6

  • 1Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. 514239052@qq.com.

Chinese Journal of Cancer
|September 16, 2015
PubMed
Summary

Wnt3a signaling is crucial in cell functions and cancer progression. This review highlights Wnt3a as a key therapeutic target in oncology, exploring its dual role in tumor development and potential inhibition strategies.

More Related Videos

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

2.0K
Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

8.9K

Related Experiment Videos

Last Updated: Apr 3, 2026

The Soft Agar Colony Formation Assay
08:01

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

114.4K
Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

2.0K
Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

8.9K

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Wnt3a is a key member of the Wnt family, regulating fundamental cellular processes like self-renewal, proliferation, differentiation, and motility.
  • Evidence indicates Wnt3a's involvement in tumor progression, acting as either a promoter or suppressor depending on the specific cancer type, primarily through the canonical Wnt signaling pathway.
  • The activity of Wnt3a signaling pathways can be modulated by various endogenous proteins and exogenous chemical compounds.

Purpose of the Study:

  • To provide a comprehensive summary of recent research on Wnt3a.
  • To highlight the significance of Wnt3a as a therapeutic target in cancer treatment.
  • To discuss the mechanisms by which Wnt3a influences tumor progression and potential inhibition strategies.

Main Methods:

  • Literature review of recent findings on Wnt3a in cancer.
  • Analysis of studies investigating the role of Wnt3a in tumor promotion and suppression.
  • Examination of known inhibitors of Wnt3a signaling pathways.

Main Results:

  • Wnt3a plays a complex, context-dependent role in cancer, influencing tumor progression.
  • The canonical Wnt signaling pathway is a major mechanism through which Wnt3a exerts its effects in cancer.
  • Several proteins and chemicals have been identified as inhibitors of Wnt3a signaling, offering therapeutic potential.

Conclusions:

  • Wnt3a is a significant factor in cancer development and progression.
  • Targeting Wnt3a signaling presents a promising therapeutic strategy for various cancer types.
  • Further research into Wnt3a inhibitors could lead to novel cancer treatments.