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Updated: Apr 3, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
[A 74 year old patient with recurrent shock caused by hypopituitarism]
Annelien Goedgezelschap1, Eddy Dejaeger2
1Dienst algemene interne geneeskunde, UZ Leuven, campus Gasthuisberg, Herestraat 49, 3000, Leuven, België. annelien.goedgezelschap@uzleuven.be.
Abstract:
This article analyzes the case of a 74 year old patient who was hospitalized four times with recurrent complaints, which consisted of hypothermia, hypotension, weakness, and a hyponatremia, and were always caused by an underlying acute infection. Laboratory results showed an hypothyroidism, a secondary adrenal insufficiency, a secondary hypogonadism, and a growth hormone deficiency, which led to a diagnosis of pituitary dysfunction. Magnetic resonance imaging of the brain showed an 'empty sella', a non-visualization of the pituitary gland caused by an herniation of a supra-sellar cistern into the pituitary fossa. Considering the lack of an underlying pituitary tumor, a treatment consisting of partial hormonal substitution was started, eventually resulting in the full recovery of the patient.
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