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Growth hormone therapy in children with CKD after more than two decades of practice

Lesley Rees1

  • 1Gt Ormond St Hospital for Children NHS Foundation Trust, London, WC1N3JH, UK. lesley.rees@gosh.nhs.uk.

Pediatric Nephrology (Berlin, Germany)
|September 16, 2015
PubMed

Insights

Recombinant human growth hormone (rhGH) therapy shows efficacy and safety in children with chronic kidney disease (CKD), improving height prognosis. This review details hormonal basis, treatment guidelines, and endocrine changes associated with rhGH in pediatric CKD patients.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Growth Hormone Therapy

Background:

  • Children with chronic kidney disease (CKD) often experience impaired growth.
  • Hormonal abnormalities in CKD contribute to growth failure.
  • Recombinant human growth hormone (rhGH) is a potential therapeutic option.

Purpose of the Study:

  • To review the evidence on the efficacy and safety of rhGH therapy in pediatric CKD patients.
  • To discuss the rationale, hormonal basis, and endocrine changes related to rhGH treatment in CKD.
  • To provide guidance on patient selection, dosage, and duration of rhGH therapy.

Main Methods:

  • Comprehensive literature review of studies on rhGH in children with CKD.
  • Analysis of data on growth outcomes, safety, and hormonal responses.
  • Synthesis of current clinical perspectives and treatment recommendations.

Main Results:

  • rhGH therapy demonstrates improved height prognosis in children with CKD.
  • Treatment is associated with specific endocrine changes.
  • Evidence supports the efficacy and safety of rhGH across all stages of CKD.

Conclusions:

  • rhGH is an effective and safe treatment for improving growth in children with CKD.
  • Understanding the underlying hormonal imbalances is crucial for rhGH therapy.
  • Guidelines for rhGH use in pediatric CKD are essential for optimal outcomes.

Keywords:
Final heightGrowthGrowth hormone

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