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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
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Diagnostic approach in lymphoplasmacytic plaque
C Mitteldorf1, G Palmedo2, H Kutzner2
1Department of Dermatology, HELIOS Klinikum Hildesheim GmbH, Hildesheim, Germany.
Journal of the European Academy of Dermatology and Venereology : JEADV
|September 16, 2015
Summary
Lymphoplasmacytic plaque (LPP) is a rare skin disease. New criteria help diagnose LPP, which can affect adults and appear beyond the lower leg, with distinct histological patterns identified.
Area of Science:
- Dermatopathology
- Histopathology
- Immunohistochemistry
Background:
- Lymphoplasmacytic plaque (LPP) is a rare, recently described skin disease.
- Characterized by dermal lymphohistiocytic infiltrate with polyclonal plasma cells.
- Typically presents as reddish-brown plaques on the lower legs of children.
Purpose of the Study:
- To establish definitive clinical and histological criteria for LPP.
- To develop a diagnostic flowchart for LPP.
- To expand understanding of LPP presentation and characteristics.
Main Methods:
- Investigated six LPP cases and reviewed ten literature cases.
- Utilized immunohistochemistry for immunoglobulin light chains, IgG, IgG4, CD31, and CD163.
- Conducted PCR for infectious agents (Borrelia, Mycobacterium, Leishmania).
Main Results:
- Identified three histological patterns: superficial band-like, deep dermal, and mixed.
- Acanthosis and interface dermatitis are key features.
- A new feature, 'free-floating' collagen bundles surrounded by histiocytes (pseudorosettes), was identified. Infectious agents were excluded.
Conclusions:
- LPP can be a long-standing condition affecting adults and other body regions.
- Reproducible clinical and histological criteria enable a diagnostic work-up for LPP.
- Distinct histological patterns and features aid in LPP diagnosis.
