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Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
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Related Experiment Video

Updated: Apr 3, 2026

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity
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Saccadic modulation of stimulus processing in primary visual cortex.

James M McFarland1, Adrian G Bondy2,3, Richard C Saunders4

  • 1Department of Biology and Program in Neuroscience and Cognitive Science, University of Maryland, College Park, Maryland 20742, USA.

Nature Communications
|September 16, 2015
PubMed
Summary
This summary is machine-generated.

Saccadic eye movements significantly modulate neural processing in the primary visual cortex (V1). This study reveals biphasic firing rate changes in V1 neurons during saccades, influenced by extra-retinal signals.

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Area of Science:

  • Neuroscience
  • Visual Processing
  • Primate Vision

Background:

  • Saccadic eye movements are crucial for primate vision.
  • Neural processing of visual input during saccades remains poorly understood.

Purpose of the Study:

  • To investigate the effects of saccadic eye movements on neural processing in primary visual cortex (V1).
  • To analyze V1 stimulus processing during saccades with high detail.

Main Methods:

  • Utilized receptive-field-based models.
  • Employed an experimental design to isolate saccade effects on retinal stimulus.
  • Analyzed V1 neuronal activity during saccades.

Main Results:

  • Discovered robust perisaccadic modulation in V1.
  • Observed biphasic firing rate changes (divisive suppression followed by additive increase) during saccades.
  • Found similar, smaller modulations from microsaccades, likely originating from the LGN via extra-retinal signals.

Conclusions:

  • Saccades induce significant, biphasic modulation of V1 activity.
  • This modulation is influenced by extra-retinal signals and potentially inherited from the LGN.
  • Results provide a basis for integrating saccades into visual cortical processing models.