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Updated: Jan 19, 2026

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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Targeted therapy: resistance and re-sensitization

Dao-Hong Chen1, Xiao-Shi Zhang2

  • 1Biomedical Research Institute, Yiling Pharmaceutical Company, Beijing, 102600, P. R. China. daohong@hotmail.com.

Chinese Journal of Cancer
|September 16, 2015
PubMed

Insights

Targeted cancer therapy shows promise but faces drug resistance. This study presents a framework to overcome resistance and improve treatment efficacy for better patient outcomes.

Area of Science:

  • Oncology
  • Pharmaceutical Innovation
  • Molecular Biology

Background:

  • The past 20 years have seen a shift from cytotoxic drugs to targeted therapies in cancer treatment.
  • Targeted agents, including synthesized compounds and antibodies, exploit molecular biology breakthroughs to target cancer pathways.
  • While effective and less toxic, targeted therapies face emerging challenges with drug resistance.

Purpose of the Study:

  • To address the limitations of targeted cancer therapy due to drug resistance.
  • To provide a systematic framework for understanding resistance mechanisms.
  • To explore alternative strategies for re-sensitizing cancer cells to therapy.

Main Methods:

  • Systematic review and analysis of drug resistance mechanisms in targeted cancer therapy.
  • Framework development for classifying resistance pathways.
  • Identification and evaluation of potential re-sensitization strategies.

Main Results:

  • Detailed categorization of known drug resistance mechanisms.
  • Identification of key molecular targets and pathways involved in resistance.
  • Proposed therapeutic approaches to overcome or circumvent resistance.

Conclusions:

  • Drug resistance remains a significant hurdle in targeted cancer therapy.
  • A systematic understanding of resistance mechanisms is crucial for developing effective strategies.
  • Further research into re-sensitization approaches can enhance the clinical benefits of targeted agents.

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