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Related Concept Videos

Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

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Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
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Genetically Encoded Voltage Indicators in Circulation Research.

Lars Kaestner1, Qinghai Tian2, Elisabeth Kaiser3

  • 1Research Centre for Molecular Imaging and Screening, Institute for Molecular Cell Biology, Saarland University, Homburg/Saar 66421, Germany. lars_kaestner@me.com.

International Journal of Molecular Sciences
|September 16, 2015
PubMed
Summary
This summary is machine-generated.

Genetically encoded biosensors offer a non-invasive method to measure cellular membrane potentials, crucial for understanding cell communication and status. These reliable fluorescent protein sensors are advancing pharmacological screening and cardiovascular research.

Keywords:
Genetically Encoded Voltage Indicators (GEVI)action potentialcardiomyocytemembrane potential

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Area of Science:

  • Biophysics
  • Cell Biology
  • Biomedical Engineering

Background:

  • Membrane potentials reflect cellular status in non-excitable cells and mediate communication in excitable cells via action potentials.
  • Genetically encoded biosensors using fluorescent proteins provide a non-invasive, biocompatible method for reading membrane potential.
  • Development of reliable genetically encoded membrane potential sensors has evolved over 15 years since the first Förster Resonance Energy Transfer (FRET) sensor designs.

Purpose of the Study:

  • To review the development of genetically encoded membrane potential sensors.
  • To illustrate the application of these sensors in pharmacological screening.
  • To discuss their utility in circulation-related basic biomedical research.

Main Methods:

  • Review of genetically encoded membrane potential sensor development.
  • Application examples in pharmacological screening.
  • Use in basic research on the circulatory system.

Main Results:

  • Reliable genetically encoded membrane potential sensors are now readily available.
  • These sensors enable non-invasive readout of membrane potential in various cell types, including cardiac myocytes.
  • The sensors have demonstrated utility in both drug screening and fundamental research.

Conclusions:

  • Genetically encoded membrane potential sensors are valuable tools for biological research and drug discovery.
  • Future developments are expected to further enhance their capabilities and applications.
  • Understanding potentials and limitations is key for optimal use in diverse research settings.