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Male Sex Associated with Increased Long-term Cardiovascular Mortality after Peripheral Vascular Surgery for

J W Budtz-Lilly1, C N Petersen2, T F Pedersen1

  • 1Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
|September 16, 2015
PubMed

Insights

Men face higher risks of death and cardiovascular events after peripheral artery disease surgery compared to women. This study analyzed long-term outcomes in over 11,000 patients undergoing vascular procedures.

Area of Science:

  • Cardiovascular Surgery
  • Vascular Surgery
  • Public Health

Background:

  • Peripheral atherosclerosis presents distinct cardiovascular risks and consequences for men and women.
  • Limited data exist on long-term outcomes and the impact of prophylactic treatments in this population.
  • Understanding sex-based differences in outcomes post-vascular surgery is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate sex-specific long-term outcomes following primary peripheral vascular surgery.
  • To evaluate the influence of medical prophylactic treatment on these outcomes, adjusted for multiple variables.
  • To compare the incidence of major adverse cardiovascular events between male and female patients.

Main Methods:

  • Analysis of Danish patients undergoing peripheral vascular surgery between 2000-2007.
  • Stratification into five distinct procedural groups based on surgical intervention.
  • Sex-based comparison of outcomes including myocardial infarction, stroke, and mortality, individually and combined.

Main Results:

  • A cohort of 11,234 patients (6,289 males, 4,945 females) was analyzed.
  • Men exhibited a higher adjusted hazard ratio for death (1.11) and myocardial infarction (1.16) compared to women.
  • No significant difference was observed in stroke risk (0.99), but men had a higher risk of any major adverse cardiovascular event (1.10).

Conclusions:

  • Men demonstrate a significantly higher risk of mortality and adverse cardiovascular events post-peripheral artery disease surgery.
  • These disparities persist despite considering disease indication, severity, and medical treatment.
  • The findings underscore the importance of sex-specific considerations in managing patients undergoing vascular surgery for peripheral arterial disease.
Abstract

Keywords:
MortalityOutcomesPeripheral vascular diseaseSex

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