Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ovarian Cycle01:27

Ovarian Cycle

5.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
5.3K
Infertility in Females01:28

Infertility in Females

5.0K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
5.0K
In Vitro Fertilization01:24

In Vitro Fertilization

1.4K
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
1.4K
Infertility in Males01:23

Infertility in Males

683
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
683
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

7.6K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
7.6K
Meiosis II01:57

Meiosis II

210.6K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
210.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How long is too long? The influence of the whole transfer procedure duration on pregnancy rates.

Journal of assisted reproduction and genetics·2026
Same author

Effects of prior cesarean delivery on subsequent pregnancy outcomes using assisted reproductive technology: a narrative review.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same author

Comment on "gonadotropin-releasing hormone antagonist protocol is associated with higher oocyte yield in young women at high risk for low oocyte retrieval".

Fertility and sterility·2025
Same author

Mechanical luteinization of follicles before oocyte retrieval is often overlooked: a case report.

Journal of assisted reproduction and genetics·2025
Same author

Luteal phase support after hCG trigger: does it support or mitigate hCG-induced potential harms?

Therapeutic advances in reproductive health·2025
Same author

Vaginal progesterone for luteal phase support in frozen embryo transfer cycles: does it deliver?

Therapeutic advances in reproductive health·2025

Related Experiment Video

Updated: Apr 3, 2026

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality
08:06

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Published on: October 18, 2024

1.0K

Luteal phase support post IVF: individualized early stop.

Linoy Segal1, Tatiana Breyzman2, Shahar Kol3

  • 1Ruth and Bruce Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, Israel.

Reproductive Biomedicine Online
|September 16, 2015
PubMed
Summary

Progesterone luteal phase support can be stopped early if strong natural progesterone production is detected on pregnancy test day. This approach, assessing endogenous luteal activity, does not impact live birth or miscarriage rates.

Keywords:
early pregnancyindividualized treatmentluteal phase supportoestradiolovarian stimulationprogesterone

More Related Videos

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

6.9K
Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
06:40

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

1.2K

Related Experiment Videos

Last Updated: Apr 3, 2026

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality
08:06

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Published on: October 18, 2024

1.0K
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

6.9K
Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
06:40

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

1.2K

Area of Science:

  • Reproductive Endocrinology
  • Infertility Treatment

Background:

  • Progesterone luteal phase support is crucial in assisted reproduction.
  • Current guidelines lack consensus on optimal duration of luteal phase support.
  • Practitioner surveys reveal varied, often empiric, cessation points for progesterone therapy.

Purpose of the Study:

  • To evaluate the feasibility of discontinuing exogenous progesterone on pregnancy test day.
  • To determine if early cessation is safe when robust endogenous luteal activity is present.
  • To compare pregnancy outcomes between early and continued luteal support.

Main Methods:

  • Retrospective analysis of 99 patients with high serum estradiol and progesterone on positive pregnancy test, who stopped support.
  • Comparison with 85 patients who continued support until week 9 of gestation.
  • Assessment of live birth and miscarriage rates between the two groups.

Main Results:

  • No significant difference in live birth rates was observed between groups.
  • Miscarriage rates were comparable across both early cessation and continued support groups.
  • Patients with high endogenous estradiol and progesterone demonstrated similar pregnancy outcomes regardless of exogenous support duration.

Conclusions:

  • Exogenous progesterone luteal phase support can be safely discontinued on pregnancy test day in patients exhibiting strong endogenous luteal activity.
  • This strategy, based on biochemical markers, may optimize treatment protocols without compromising pregnancy success.
  • Further research is warranted to validate these findings and refine clinical guidelines for luteal phase support cessation.