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Related Experiment Video

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Right ventricular diastolic function and exercise capacity in COPD.

Brett E Fenster1, Kristen E Holm2, Howard D Weinberger1

  • 1National Jewish Health, Division of Cardiology, Denver, CO, United States.

Respiratory Medicine
|September 16, 2015
PubMed
Summary
This summary is machine-generated.

Right ventricular diastolic function, specifically the tricuspid valve E/A ratio, is linked to exercise capacity in COPD patients. This suggests RV diastolic dysfunction may worsen exercise intolerance in COPD.

Keywords:
COPDDiastolic functionExerciseRight ventricle

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Area of Science:

  • Cardiology
  • Pulmonology
  • Echocardiography

Background:

  • Exercise capacity is reduced in COPD, but pulmonary factors alone do not fully explain this.
  • Right ventricular diastolic function (RVDF) is a potential, under-explored contributor to exercise limitation in COPD.

Purpose of the Study:

  • To investigate the association between RVDF and exercise capacity in patients with COPD.
  • To determine if specific echocardiographic markers of RVDF correlate with 6-minute walk test (6MWT) distance.

Main Methods:

  • Fifty-one COPD patients underwent echocardiography, spirometry, and 6MWT.
  • RVDF assessed via tricuspid valve (TV) E/A ratio, TV e', TV deceleration time, and TV E/e' ratio.
  • Multiple linear regression analyzed associations between RVDF markers and 6MWT distance, adjusting for covariates.

Main Results:

  • Nearly half the cohort had GOLD stage III/IV COPD; all had preserved left ventricular ejection fraction.
  • A higher TV E/A ratio was significantly associated with increased 6MWT distance (p=0.001).
  • Other RVDF echocardiographic parameters (TV e', TV DT, TV E/e') showed no significant association with 6MWT distance.

Conclusions:

  • In moderate to severe COPD patients with normal LVEF, the TV E/A ratio is independently associated with exercise capacity (6MWT distance).
  • RV diastolic dysfunction may be an independent factor contributing to exercise intolerance in COPD.