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Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
Open Globe Injuries Presenting With Normal or High Intraocular Pressure
Jordan A Margo1, Samantha Feldman, Hampton Addis
1Department of Ophthalmology and Visual Sciences (J.A.M., O.S.), University of Maryland, Baltimore, MD; University of Maryland School of Medicine (S.F., H.A.), Baltimore, MD; and Departments of Radiology (U.K.B.) and Epidemiology (N.E.), University of Maryland, Baltimore, MD.
High intraocular pressure (IOP) is common in open globe injuries and may indicate posterior injury. Elevated IOP at presentation predicts worse vision outcomes in these trauma patients.
Area of Science:
- Ophthalmology
- Trauma Surgery
- Ocular Trauma
Background:
- Open globe injuries are severe ocular emergencies.
- Intraocular pressure (IOP) is a critical factor in ocular health.
- The relationship between IOP and open globe injuries requires further investigation.
Purpose of the Study:
- To investigate the frequency and clinical significance of intraocular pressure (IOP) in patients with open globe injuries.
- To determine the association between IOP levels and injury characteristics.
- To evaluate the impact of IOP on visual outcomes in open globe injuries.
Main Methods:
- Retrospective chart review of open globe injury cases at a level 1 trauma center.
- Analysis of demographics, clinical findings, and computed tomography (CT) scans.
- Measurement of intraocular pressure (IOP) in affected and unaffected eyes, alongside visual acuity assessments.
Main Results:
- Of 132 eyes with open globe injury, IOP was recorded in 38 (28%).
- Twenty-three (59.4%) eyes had an IOP greater than 10 mm Hg; six (16.2%) had IOP > 21 mm Hg.
- Higher presenting IOP correlated with posterior open globe injury and predicted worse visual acuity (light perception or worse).
Conclusions:
- High intraocular pressure (IOP) does not rule out open globe injury and is a frequent finding.
- Elevated IOP in open globe injuries is associated with posterior segment involvement.
- Presenting IOP is a significant predictor of visual prognosis in patients with open globe injuries.
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