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Pediatric Origins of Nephrolithiasis-Associated Atherosclerosis

Kirsten Kusumi1, Sally Smith2, Evan Barr-Beare3

  • 1Division of Nephrology, Department of Pediatrics, Nationwide Children's Hospital/The Ohio State University, Columbus, OH.

The Journal of Pediatrics
|September 16, 2015
PubMed

Insights

Kidney stones in children may signal early signs of atherosclerosis, a hardening of the arteries. Specific urine proteins like osteopontin and fibronectin 1 are linked to this increased vascular risk.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Research
  • Vascular Biology

Background:

  • Nephrolithiasis (kidney stones) is increasingly diagnosed in children.
  • Atherosclerosis, a condition typically associated with adults, may have origins in childhood.
  • Understanding the link between pediatric kidney stones and vascular disease is crucial for long-term health.

Purpose of the Study:

  • To investigate if atherosclerosis associated with kidney stones begins in childhood.
  • To explore the relationship between kidney stones and specific atherosclerosis-related proteins in pediatric patients.

Main Methods:

  • A study compared children aged 12-17 with and without kidney stones.
  • Carotid artery intima-media thickness (cIMT) was measured using ultrasound.
  • Urine levels of fibronectin 1, macrophage scavenger receptor 1, osteopontin, and vascular cell adhesion molecule 1 were analyzed.

Main Results:

  • Children with kidney stones exhibited increased cIMT, indicating early atherosclerosis.
  • Urine osteopontin and fibronectin 1 levels were significant predictors of cIMT.
  • These findings suggest a pediatric origin for nephrolithiasis-associated atherosclerosis.

Conclusions:

  • Preliminary evidence suggests that atherosclerosis linked to kidney stones can originate in childhood.
  • The study identifies potential molecular reasons for the association between kidney stones and vascular disease.
  • Further research is warranted to confirm these pediatric origins and explore preventative strategies.
Abstract

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