Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities
Christine M M Hendriks1, Trevor M Penning2, Tianzhu Zang2
1Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany.
Bioorganic & Medicinal Chemistry Letters
|September 16, 2015
Abstract:
Pentafluorosulfanyl-containing analogs of flufenamic acid have been synthesized in high yields. Computationally, pKa, LogP and LogD values have been determined. Initial bioactivity studies reveal effects as ion channel modulators and inhibitory activities on aldo-keto reductase 1C3 (AKR1C3) as well as COX-1 and COX-2.
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