Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.5K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.5K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

86.5K
Overview
86.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Designing studies on the effectiveness of physical training in patients with cognitive impairment.

Zeitschrift fur Gerontologie und Geriatrie·2008
Same author

NBT-PABA test to assess efficiency and kinetics of substituted proteolytic enzyme action in pancreatic duct ligated minipigs.

Journal of animal physiology and animal nutrition·2008
Same author

Dyschromatosis universalis hereditaria: evidence for autosomal recessive inheritance and identification of a new locus on chromosome 12q21-q23.

Clinical genetics·2008
Same author

MR imaging, proton MR spectroscopy, ultrasonographic, histologic findings in patients with chronic lymphedema.

Lymphology·2008
Same author

Restaging of patients with lymphoma. Comparison of low dose CT (20 mAs) with contrast enhanced diagnostic CT in combined [18F]-FDG PET/CT.

Nuklearmedizin. Nuclear medicine·2008
Same author

Biowaiver monographs for immediate release solid oral dosage forms: pyrazinamide.

Journal of pharmaceutical sciences·2008
Same journal

Influence of Body Mass Index on Perioperative Outcomes of Oncologic Head and Neck Free Flaps: Comprehensive Analysis Using a Prospective Institutional Database.

Journal of reconstructive microsurgery·2026
Same journal

Homocysteine Levels as a Potential Contributor to Impaired Wound Healing in Plastic and Reconstructive Surgery.

Journal of reconstructive microsurgery·2026
Same journal

Infrared Temperature Monitoring in Vascularized Flaps with Simulated Arterial and Venous Thrombosis: An Animal Study.

Journal of reconstructive microsurgery·2026
Same journal

Sequential, Noninvasive, Neurosensory Monitoring During Chemotherapy: Clinical Consequences of Identifying Neuropathy.

Journal of reconstructive microsurgery·2026
Same journal

"Finger-Touch Approach" for Novice Microsurgical Assistants: A Simulation Study.

Journal of reconstructive microsurgery·2026
Same journal

Assessing the Availability and Need for Microsurgery-Trained Reconstructive Surgeons in Sub-Saharan Africa.

Journal of reconstructive microsurgery·2026
See all related articles

Related Experiment Video

Updated: Apr 3, 2026

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

3.0K

Autologous Lymph Node Transfers.

C Becker1

  • 1Department of Plastic Surgery, Hôpital Européen Georges Pompidou of Paris, Paris, France.

Journal of Reconstructive Microsurgery
|September 16, 2015
PubMed
Summary
This summary is machine-generated.

Lymphedema, a chronic condition often following cancer treatment, can be improved by fatty flap lymph node transfer. This procedure aids lymphatic vessel regrowth, benefiting both secondary and congenital lymphedema cases.

More Related Videos

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats
09:25

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

Published on: May 8, 2020

8.5K
Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

24.2K

Related Experiment Videos

Last Updated: Apr 3, 2026

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

3.0K
An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats
09:25

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

Published on: May 8, 2020

8.5K
Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

24.2K

Area of Science:

  • Oncology
  • Vascular Surgery
  • Regenerative Medicine

Background:

  • Lymphedema is a chronic, progressive condition frequently developing after cancer treatments like lymph node dissection and radiation.
  • Breast and pelvic cancer patients are particularly susceptible to secondary lymphedema.
  • Current treatments aim to manage symptoms, but restorative options are limited.

Purpose of the Study:

  • To investigate the efficacy of autologous lymph node transfer in reconstructing damaged lymphatic regions.
  • To explore the role of vascular endothelial growth factor C (VEGF-c) in promoting lymphatic vessel regeneration following lymph node transfer.
  • To assess the potential of this reconstructive approach for both secondary and congenital lymphedema.

Main Methods:

  • Utilizing fatty flaps enriched with lymph nodes for anatomical reconstruction in lymphedema patients.
  • Postulating the mechanism of action involves cytokines, such as VEGF-c, present in the fatty tissue surrounding the lymph nodes.
  • Applying autologous lymph node transfer principles to patients with both secondary and hypoplastic congenital lymphedema.

Main Results:

  • Fatty flap lymph node transfer shows promise in restoring anatomy and function in lymphedema.
  • The presence of VEGF-c in the transferred tissue is hypothesized to stimulate lymphatic vessel regrowth.
  • Positive improvements were observed in patients with congenital lymphedema, suggesting broad applicability.

Conclusions:

  • Autologous lymph node transfer is a viable reconstructive strategy for secondary lymphedema post-cancer treatment.
  • The procedure may promote lymphatic regeneration through VEGF-c mediated mechanisms.
  • This technique offers a promising therapeutic avenue for various forms of lymphedema, including congenital cases.