Related Experiment Video

Updated: Apr 3, 2026

A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection
05:21

A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection

Published on: August 14, 2019

26.3K

Efficacy and effectiveness of live attenuated influenza vaccine in school-age children

Kathleen Coelingh1, Ifedapo Rosemary Olajide2, Peter MacDonald1

  • 1a 1 MedImmune, Gaithersburg, MD, USA.

Expert Review of Vaccines
|September 16, 2015
PubMed

Insights

Live attenuated influenza vaccine (LAIV) shows high efficacy in children aged 5 and older. This review confirms its effectiveness in school-aged children, expanding on data for younger age groups.

Area of Science:

  • Vaccinology
  • Pediatric Infectious Diseases
  • Public Health

Background:

  • Live attenuated influenza vaccine (LAIV) has demonstrated high efficacy in young children (2-6 years).
  • Limited data exist regarding LAIV efficacy and effectiveness in older, school-aged children (≥5 years).

Purpose of the Study:

  • To review and synthesize published data on the efficacy and effectiveness of LAIV in children aged 5 years and older.
  • To assess the value of LAIV for school-aged populations.

Main Methods:

  • A comprehensive literature search was conducted using the QUOSA database (Elsevier).
  • Included studies published from January 1990 to June 2014.
  • Search terms included 'FluMist', 'LAIV', 'CAIV', 'cold adapted influenza vaccine', 'live attenuated influenza vaccine', 'live attenuated cold adapted', and 'flu mist'.
  • Evaluated studies encompassed randomized controlled trials, effectiveness studies, and indirect protection studies.

Main Results:

  • The review identified considerable evidence supporting LAIV efficacy in school-aged children.
  • Effectiveness data also indicate a positive impact of LAIV in this demographic.

Conclusions:

  • LAIV demonstrates significant efficacy and effectiveness in school-aged children (≥5 years).
  • These findings support the use of LAIV in older children, complementing existing data for younger age groups.

Keywords:
effectivenessefficacyinfluenza vaccinelive attenuated influenza vaccineschool-age children

More Related Videos

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers06:34

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

38.4K
A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies04:47

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

Published on: February 23, 2018

8.3K

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
54.0K
Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
42