Related Experiment Video
Updated: Apr 3, 2026

One-channel Cell-attached Patch-clamp Recording
Published on: June 9, 2014
The Piezo Mechanosensitive Ion Channels: May the Force Be with You!
Eric Honoré1, Joana Raquel Martins1, David Penton1
1Institut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, Valbonne, France.
Abstract:
Piezo1 and Piezo2 are critically required for nonselective cationic mechanosensitive channels in mammalian cells. Within the last 5 years, tremendous progress has been made in understanding the function of Piezo1/2 in embryonic development, physiology, and associated disease states. A recent breakthrough was the discovery of a chemical opener for Piezo1, indicating that mechanosensitive ion channels can be opened independently of mechanical stress. We will review these new exciting findings, which might pave the road for the identification of novel therapeutic strategies.
Related Concept Videos
Mechanically-gated Ion Channels
Mechanically-gated Ion Channels
Ion Channels
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
G-Protein Gated Ion Channels
Sensory...
Non-gated Ion Channels
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
Non-gated Ion Channels

